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A substance must receive a marketing authorisation demonstrating safety, efficacy, and quality before it can be legally sold or supplied as a medicine

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There is a well-recognized phenomenon in gut-hormone pharmacology whereby a signal that potently slows gastric emptying on first exposure gradually loses that particular effect under continuous stimulation, even as its central appetite-suppressing effect persists

Tropical Journal of Pharmaceutical Research , 16 (6), 12851292

OpenSource Diets formula D12451) or, if they were previously on an LD, they were maintained continued on LD (termed lean control mice)

Research suggests that weight loss achieved with medication alone tends to be modest, and individuals may regain weight once the medication is discontinued or if lifestyle changes are not maintained