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Weight-loss medications have moved from fringe conversations to mainstream healthcare discussions in a remarkably short space of time

This is why a holistic view is essential

The through line of history is that people will try to sell anything with all sorts of fantastical claims, Joshua Sharfstein, a health-policy professor at Johns Hopkins and a former principal deputy commissioner of the F.D.A., told me

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It is determined by body composition, metabolic function, physical capability, and long-term sustainability