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3 It works by: Stimulating insulin release when blood sugar is high (glucose-dependent, so it doesnt cause insulin release when blood sugar is normal) Reducing glucagon secretion (glucagon is a hormone that raises blood sugar) Slowing stomach emptying, which reduces blood sugar spikes after meals Acting on appetite centres in the brain to reduce hunger Why the combination works When both medications are together, theyre addressing multiple aspects of blood sugar control: Metformin focuses on the glucose our liver produces (fasting blood sugar) Mounjaro focuses on the glucose spikes after meals and helps with weight loss Together, they improve insulin sensitivity in different ways Significantly, because Mounjaro only stimulates insulin release when blood glucose is elevated, adding it to metformin doesnt substantially increase the risk of hypoglycaemia (low blood glucose)

Your primary care provider or endocrinologist should manage this monitoring and adjust your levothyroxine dose accordinglyPlexusDx can coordinate with your existing thyroid care team to ensure seamless treatment

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10 In patients with MS, the anti-inflammatory and potentially neuroprotective effects of semaglutide may confer benefits beyond weight loss, as demonstrated in preclinical research