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Conclusion: FOXO4-DRI promotes the nuclear export of phosphorylated P53 by inhibiting the binding of FOXO4 to P53 in endothelial cells, thereby facilitating the apoptosis of senescent endothelial cells and alleviating aging

At higher concentrations, the relative loss is smaller, but it still occurs

GHK-Cu delivers copper for enzymatic activity Advantages Good cosmetic efficacy data, lipophilic for skin penetration Disadvantages Different mechanism, no copper delivery Peptides Related to GHK-Cu# GHK-Cu occupies a distinctive niche among healing and regenerative peptides due to its dual nature as both a signaling molecule and a copper delivery vehicle

Nature 584 , 535546 (2020)

Fish Physiol Biochem

This systems-level activity has made it an important model for studies of skin physiology, connective tissue biology and regenerative signalling