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In macrophages exposed to conidia, mitophagy is activated to remove ROS-damaged mitochondria and prevent excessive inflammasome activation ( Cryptococcus neoformans infection induces excessive mitophagy, blunting immune cell activation and cytokine production ( 4.5 Fungal-induced mitochondrial signaling and innate immune activation Mitochondria serve as signaling platforms for innate immune pathways such as MAVS-dependent antiviral signaling, the NLRP3 inflammasome, and cGAS-STING
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Overall, increased oxygen consumption, energy production, and lactic acid production during high-intensity exercise can increase free radicals and oxidative stress, which can cause damage to cells and tissues if not adequately neutralized by the bodys antioxidant defense system
placebo ( n = 8, 66.7%) group, P 0.11)
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Multiple studies have demonstrated that targeting the TGF-/SMAD pathway may be an effective therapy to asthma [39, 40]
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