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Key factors influencing dose selection include: Treatment goals : Whether the primary aim is glycaemic control, weight reduction, or cardiovascular risk reduction Baseline HbA1c and blood glucose levels : Higher values may eventually require higher maintenance doses Body weight and BMI : Particularly relevant for weight management indications Renal function : Most GLP-1 medications (semaglutide, liraglutide, dulaglutide) do not require dose adjustment for kidney impairment, but exenatide and lixisenatide should be used with caution or avoided in severe renal impairment Concurrent medications : Especially other glucose-lowering agents that might increase hypoglycaemia risk Previous medication tolerance : History of gastrointestinal sensitivity influences titration speed Cardiovascular history : Some GLP-1 medications have proven cardiovascular benefits at specific doses Diabetic retinopathy status : Rapid improvement in blood glucose can temporarily worsen retinopathy, particularly with semaglutide [22] [23] Your doctor will typically schedule regular follow-up appointments during the initial months of treatment

The list price of Wegovy is $1,350 for a 28-day supply

Daz-Garca and Yellen, 2019)

NG28 Blood glucose management chapter NICE

Insurance, HSA, and FSA: reducing your out-of-pocket cost Understanding your payment options can significantly reduce what you actually spend on tirzepatide, whether brand-name or compounded

For contexts where rapid and reliable serum levels are essential, injection remains preferred