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A casecontrol study showed a higher risk of developing breast cancer in women with two specific single nucleotide polymorphisms in the POLK gene compared with controls 48

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This issue has been attributed to the mode of action of these antagonists: those blocking CAP-, proton-, and heat-induced TRPV1 activation result in hyperthermia, whereas those sparing proton-induced activation do not lead to hyperthermia 33,35

Serious adverse events were infrequent and similar between groups

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