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It activates certain pathways that lead to an increase in GLP-1 production

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To specifically delineate the contribution of Nrf2 on the protective effect of metformin on OA progression, an MIA-induced OA mouse model was established using Nrf2 KO mice again

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In contrast, for wellness use with normal labs, the rationale is weaker and alternatives should be discussed

very rare reports of water retention or increased hunger