That choice addresses the symptom but not the mechanism and it introduces a new problem
Semaglutide replaces that alanine with alpha-aminoisobutyric acid (Aib)
The logic behind this approach is that the concomitant activation of GLP1 and estrogen receptors may drive additional favorable effects, when compared with the individual activation of these pathways, which are known to conduct, on their own, beneficial metabolic actions on energy and glucose homeostasis 52

This orientation allows it to interact with ROS on both sides, helping stabilize and protect the cell.19 Laboratory studies show that this structural advantage may make astaxanthin 10100 times more potent than vitamin E or beta-carotene in quenching singlet oxygen, one of the most reactive and damaging forms of oxygen in the body.20 40 Because of this positioning, astaxanthin can influence how cells respond to stress, potentially protecting lipids, proteins, and DNA from oxidation.39 In human studies, its effects appear to stem mainly from two biological roles: reducing oxidative and inflammatory stress and supporting mitochondrial health the processes that govern cellular energy and resilience.21 41 These mechanisms appear to underlie many of the outcomes observed in clinical research

Compounding pharmacies have been able to step in and fill some of those gaps in the marketplace. Most states have similar compounding rules, though some states including California and Texas are stricter than others
Schwarzschild MA, Ascherio A, Casaceli C, et al