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Safety endpoints included incidence of adverse events, number of hypoglycemic episodes, incidence of anti-semaglutide antibodies at follow-up, and change in vital signs, electrocardiogram (ECG) readings, physical examination, and laboratory tests (hematology, biochemistry, calcitonin, and urinalysis)

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However, severe persistent vomiting (more than 3 episodes per day for more than 2 days), signs of pancreatitis (severe abdominal pain radiating to the back), or allergic reactions (hives, difficulty breathing, facial swelling) warrant immediate protocol cessation and medical attention