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NNMT is upregulated in adipose tissue in obesity, and its inhibition is studied as a potential strategy to modulate NAD+ metabolism and metabolic gene expression

Both Tesamorelin and AOD-9604 show preferential reduction of abdominal/visceral fat, but through different mechanisms

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NNMT (nicotinamide N-methyltransferase) is an enzyme found in fat cells and other tissues that can become overactive in certain metabolic conditions

That single block sets off a chain of changes inside fat cells

References Boachie, J., Adaikalakoteswari, A., Samavat, J., & Saravanan, P