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As a consumer representative, I worry what placing a bulk substance on the list conveys in terms of FDA approval, said committee member Todd Durham, senior vice president of clinical outcomes and research at the Foundation Fighting Blindness, who voted no on adding these peptides to the list

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The Frias 2023 Phase 2 in T2D showed cagrilintide+semaglutide produced a -2.2 percentage-point HbA1c reduction at 32 weeks versus -1.8 for semaglutide alone

However, once DHEA becomes sulfated to DHEA-S, it is unable to cross the blood-brain barrier (DHEA is non-polar and crosses the blood-brain barrier easily, whereas DHEA-S is polar and does not cross into the brain from periphery)

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