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Oxidative stress serves as a key pathogenic node, PAGln induces oxidative stress in atrial myocytes (HL-1) via 2AR activation, characterized by elevated ROS production, increased NOX activity, and reduced SOD activity (Fang et al., 2022)
For all real-time RT-PCR experiments, each condition was in triplicate
Additionally, its antioxidant properties contribute to a robust immune system, defending against the impact of free radicals and environmental stressors
Acknowledgements Work in the Houtkooper group is financially supported by an ERC Starting grant (no
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