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The 4872 hour spacing and site rotation rules apply at every dose level

After 812 h, the microbial metabolites 5-(3,4-dihydroxyphenyl)--valerolactone and 5-(3-methoxy-4-hydroxyphenyl)--valerolactone (see section 6.1 Pre-systemic metabolism: role of gut microbiota) were present in urine ( As for the half-lives (t) of Pycnogenol components and metabolites in vivo , small molecules revealed short to intermediate terminal t of 4.42 2.47 h for caffeic acid, 6.87 3.83 h for ferulic acid and 8.89 2.81 h for taxifolin (Figure 2) (55)

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