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Adverse effects observed in trials include: Nausea and vomiting particularly during dose escalation Diarrhoea or constipation Decreased appetite Injection site reactions Fatigue and dizziness Gallbladder-related events (including gallstones), consistent with effects observed with other GLP-1based therapies [9] Rare cases of pancreatitis , a risk associated with the GLP-1 receptor agonist class [10] [3] Because retatrutide is not licensed in the UK, the MHRA has not issued specific prescribing or dosing guidance for this compound

The classification criteria then include a history of chronic widespread pain and the presence of 11 or more out of 18 tender points (TPs)

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Avoid strenuous physical activity for 24 hours after your injection to prevent additional swelling, bruising, or tenderness

This article explores the evidence, clinical considerations, and practical guidance for patients and healthcare professionals

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