In 2022, the American Medical Association found that 83.2% of appealed prior authorization denials resulted in a full or partial overturn
Swelling in the center of your retina, called macular edema, may develop or get worse Abnormal new blood vessels can grow more rapidly on the retina or optic nerve Bleeding into the jelly-like vitreous gel inside your eye may occur These changes typically appear within the first three to six months of treatment The strongest link between semaglutide and eye problems involves early worsening of diabetic retinopathy when blood sugar improves rapidly, especially in patients who already have retinal disease
P.PoulosS
In terms of side effects and discontinuation rate (people who drop out because they couldn't handle it anymore), Tirzepatide was reported to have more people experiencing side effects and nearly 2X drop out rate compared to Semaglutide
In the community-based randomized trial by Messier et al., diet and exercise led to a statistically significant but small difference in knee pain over 18 months, with uncertain clinical importance (Messier et al., 2022)
in December, and the company expects Health Canada approval by the end of 2026