Nausea occurred at significantly elevated rates across all dose levels compared to placebo
Still, researchers caution that findings are largely preliminary and drawn from small cohorts rather than large, sex-stratified clinical trials
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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
Protection of the endothelium and the gastric and intestinal mucosa
Unlocking gut-liver-brain axis communication metabolites: energy metabolism, immunity and barriers