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measured MMP1, MMP2, TIMP1, and TIMP2 gene expression in human adult dermal fibroblasts exposed to GHK-Cu at 0.01, 1, and 100 nanomolar concentrations and found dose-dependent increases in both MMPs and their inhibitors 11

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This peptide is derived from a naturally occurring protein found in human gastric juice

The angiogenic action appears tied to T4s actin-binding motif: Philp et al., FASEB J 2003 demonstrated that this seven-residue site is essential for promoting endothelial migration and vessel formation

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