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Subjects subsequently underwent a mandatory taper schedule, with complete corticosteroid discontinuation by Week 19

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While p53 modulators, including FOXO4-DRI, MDM2 inhibitors, and USP7 inhibitors have shown senolytic effects by selectively eliminating senescent cells or promoting their apoptosis in the laboratory, translating these findings to the clinic have so far been unsuccessful

Not for everyone Fasting may be unsafe for some people with low blood pressure or heart disease or people who take certain medications

Thats where a well-thought-out clinic policy for GLP1 use makes all the difference

Sandi: Yeah, I wish that I had heard that drum beat in the 90s when you started because I was one of those people