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Polycystic ovary syndrome (PCOS) is a common hormonal disorder that affects women of reproductive age and is characterized by irregular menstrual cycles, excessive hair growth, acne, and obesity

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Manifestations of hepatic oxidative damage include dysregulation of lipid metabolism (leading to steatosis), hepatocyte degeneration and death, and activated immune response (leading to inflammation and fibrosis/cirrhosis)

In addition, there is evidence from preclinical studies that ES (POS in particular) affects mitochondria in the brain