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[74] Fruit and iron were also part of the diet, and it appears that at this point, Minot and Murphy were not quite sure that the liver was a very important factor

Daily intraperitoneal administration for 11 days reduced body weight gain, decreased white adipose tissue mass by approximately 35%, and reduced adipocyte size, while food intake between treated and control groups did not differ significantly

No participants developed antibodies against the peptide, and no serious adverse events led to treatment withdrawal

Furthermore, only 1.2% of the B12 in an oral supplement is actually absorbed in the intestines