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Symptoms can include unexplained fatigue, pins and needles or numbness, balance or memory problems, vision changes, muscle weakness or a sore, red tongue

You might have to take a B12 supplement or try a new medication

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The accumulation of senescent cells, often referred to as the "old cell burden," is a concern because these cells can secrete a variety of harmful substances as part of the senescence-associated secretory phenotype (SASP)

4), aside from increased 5-HT reuptake in astrocytes, increased oxidative and nitrosative stress leads to activation of indoleamine 2,3-dioxygenase (IDO), and increased proinflammatory cytokines activate tryptophan 2,3-dioxygenase (TDO) [318]