The tradeoff is data scope
Products containing the herb berberine offer only a few pounds of weight loss, while many dietary supplement weight loss products contain stimulants such as sibutramine and laxatives such as phenolphthalein, which increase the risk of heart attacks, strokes and cancer
PMID: 14501183
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Everyones body responds differently to medications
In Australia, tanning nasal sprays sold online contain a variety of ingredients, but according to a spokesperson for the Therapeutic Goods Administration (TGA), those containing Melanotan I and II are classified as Prescription only medicines (Schedule 4) and are illegal to sell as tanning agents in Australia