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(CNN) The US Food and Drug Administration issued a warning Tuesday about compounded versions of the drug semaglutide, which is approved for the treatment of diabetes and excess weight
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Animal studies suggest that GLP-1 receptor activation may modulate dopamine signaling in these pathways, potentially dampening the reward value assigned to food stimuli
Notably, Retatrutides 28% nausea rate compares favorably to semaglutides 44% nausea rate in comparable trials
Follow-up studies to address concerns about serious potential problems like medullary thyroid cancer have been short or not always completely reassuring
Nature (1983) 304:36871
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