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However, diabetic patients with concomitant sporadic medullary thyroid carcinomas that express GLP1R in 2030% should probably be excluded from any incretin treatment for their diabetes
Among the most well-understood behavioral mechanisms of GLP-1 in the brain is its ability to restrict feeding behavior through its targeting of the PVH of the hypothalamus and the central amygdala [50, 54]
10.1016/j.clinthera.2017.10.016 86
The metabolic enhancements seem to be partially independent of weight reduction, indicating direct effects on various tissues that express GLP-1 receptors
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