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Cardioprotective actions include the inhibition of TLR4/NF- B/NLRP3 signaling, reduction of cytokine levels (such as IL-6 and IL- 1), and prevention of myocardial remodeling and dysfunction

doi: 10.1016/j.jsbmb.2016.05.009 138

In June, the FDA approved a higher-dose formulation semaglutide for treatment of obesity, 4 thanks in part to findings from the STEP (Semaglutide Treatment Effect in People) trials of people with obesity

What is the FDA Application Number

More serious but rare side effects can include pancreatitis, gallbladder problems, and kidney issues

This elevation is not limited to healthy populations