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But theyre also a reminder of what sustained investment in basic science can achieve. As UAB researchers continue to study how these drugs work and what comes next, their findings are helping move the conversation beyond hype, while working toward a clearer understanding of one of the most significant medical breakthroughs of the past decade.

Finally, GSH depletion was designated as necessary to induce the redox unbalance characteristic of the induction phase of the mitochondrial pathway but not sufficient per se to assure the execution phase of apoptosis

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