If you stop taking semaglutide, weight regain is highly likely for most people
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In case of autoimmune components, auto-antibodies directed at fetal brain proteins might cause BBB damage (Zimmerman et al., 2007)
Specifically, there are concerns that GLP-1 agonists may cause a loss of muscle mass and function
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However, unlike GPX7, which is a transmembrane protein that contains a C-terminal KEDL endoplasmic reticulum localization sequence and a highly conserved N-terminal transmembrane domain (TMD) (Yoboue et al., 2017)