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On the other hand VEGF is researched for its role in angiogenesis, the formation of new blood vessels from pre-existing vessels

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However, DPP-4 inhibitors (such as sitagliptin or linagliptin) should be discontinued when initiating semaglutide, as both drug classes work through incretin pathways, and combined use offers no additional glycemic benefit while potentially increasing adverse effects

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What we can foresee is an annual cycling in and out of the GLP-1 drug universe not dissimilar to the cycling in/out of diets more generally