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September 17, 2025
doi: 10.1136/ard.2005.037176 111 ChenZKimSJEssaniABVolinMVVilaOMSwedlerWet al
Gold KA, Kim ES, Liu7 DD, Yuan P, Behrens C, Solis LM, Kadara H, Rice DC, Wistuba II, Swisher SG , Lee JJ, Hong WK
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When peptides are not synthesized or compounded under proper conditions, they can degrade or become unstable, which might lead to incomplete sequences or harmful byproducts
44, 77 Methymalonic acid, a metabolite of PPA, results in abnormal mitochondrial morphology, 78 tissue specific ETC dysfunction, 79 inhibition of the complex I and II function when interacting with complex III in the brain 80 and reductions in reduced glutathione, 78 similar to the patient cohort presented and the PPA animal model
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