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Note that growth factor they refer to is actually peptides, which dont have particular actions for acne at all

Schoenenberger GA, Maier PF, Tobler HJ, Wilson K, Monnier M

Doherty, C

[16] A 2024 observational study with 32 subjects applying retinaldehyde three nights per week for eight weeks showed 12% visible change in fine lines and 19% improvement in hyperpigmentation with no sensitization

They suggest that cellular energy, antioxidant reserve and toxic burden may influence severity, treatment response and recovery