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In this work, we show that ROXY9 has weak GSH-dependent de-glutathionylation activity on glyceraldehyde-3-phosphate dehydrogenase (GAPDH), but no oxidase or reductase activities on other substrates like HED, Cys-SG, cumene hydroperoxide (CHP) or roGFP2

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Lu, S.C., et al., Insulin and Glucocorticoid Dependence of Hepatic Gamma-Glutamylcysteine Synthetase and Glutathione Synthesis in the Rat Studies in Cultured-Hepatocytes and Invivo

Glutathione levels naturally decline with aging, chronic disease states, and exposure to environmental toxins

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Fungal Biol Biotechnol