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, Biochem Pharmacol 163:481-492 , USA , 2019 In aged mice after muscle injury, NNMT inhibition raised peak tibialis anterior torque by roughly 70% and nearly doubled fiber cross-sectional area compared with controls - activation of senescent muscle stem cells
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When to hold versus reduce the dose If side effects at a new dose level are significant but manageable, hold at that dose for an additional two to four weeks before escalating
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