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Similarly, folate requirements rise during active cell division, and inadequate folate can limit the effectiveness of B12 therapy

Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum

In addition, once-daily administration of 1 mg oral hydroxocobalamine caused the studied children's levels of homocysteine to increase and their levels of methionine to decrease, while the reverse happened when hydroxocobalamine was given intramuscularly

Exact figures vary by study design and should be read from the individual publications

If single morning administration produces satisfactory results, adding complexity provides no advantage

The safety of the treatment for the baby is not fully known