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Berberine, an alkaloid extracted from traditional Chinese medicine, binds to the bitter taste receptor TAS2R38 and activates the PLC signaling pathway to stimulate GLP-1 secretion in STC-1 cells [193]

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41, 42 we found that, in cholangiocytes isolated from cromolyn sodium-treated BDL rats, basal cAMP levels were significantly decreased versus BDL cholangiocytes (0.3980.042 pmol/1 10 6 cells (BDL) vs 0.2160.029 pmol/1 10 6 cells (BDL+cromolyn))

The peptide also demonstrates sophisticated regulation of matrix metalloproteinases (MMPs), the enzymes responsible for breaking down old or damaged tissue components