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Individuals with severe obesity, a long history of failed dieting, or metabolic conditions often see the strongest case for continued therapy
GLP-1 is produced via the proteolytic cleavage of proglucagon
When the body burns fat, it sometimes releases stored water and nutrients faster than the skin can adapt
The ability of the conjugate to decrease body weight and to improve glucose control is absent in GLP-1R knockout mice and is preserved in DIO mice even at doses subthreshold for the GLP-1RA and tesaglitazar alone to improve glucose control
Dermatol Ther 34:e14976
GI symptoms: Nausea, bloating, constipation, or fatigue are common
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