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Gaillard PJ, Appeldoorn CC, Dorland R, van Kregten J, Manca F, Vugts DJ, et al

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Compared with the CN group, the number of dark neurons in the Purkinje cell layer was notably reduced in the CP group (0.665 0.335/10 m 2 with P = 0.0117) and glycitin treatment groups [F (5, 30) = 14.16, P = 0.0029] at doses of 5, 10, and 20 mg/kg (0.495 0.165/10 m 2 with P = 0.0075, 0.18 0.18/10 m 2 with P = 0.0035, and 0.165 0.165/10 m 2 with P = 0.0033 respectively, Figures 4EI)

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These experimental results demonstrated that NP4 could activate macrophages, facilitate DCs maturation, increase infiltration of cytotoxic T cells, activate the mouse immune system, and inhibit tumor growth in osteosarcoma