This article examines the side effect profile of B12 therapy in older adults, covering common reactions such as injection site discomfort and gastrointestinal symptoms, rare serious adverse events requiring urgent medical attention, important drug interactions with medications like proton pump inhibitors and metformin, and evidence-based dosing guidance aligned with NICE and BNF recommendations for safe, effective B12 replacement in this vulnerable population
This should be discussed with the provider
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However, do not stop prescribed B12 injections or tablets for confirmed deficiency (such as pernicious anaemia) without consulting your GP, as this could lead to serious health consequences
Clinical efficacy and safety of sodium-glucose cotransporter protein-2 (SGLT-2) inhibitor, glucagon-like peptide-1 (GLP-1) receptor agonist, and Finerenone in type 2 diabetes mellitus with non-dialysis chronic kidney disease: a network meta-analysis of randomized clinical trials
63,64 DR activation is also found in humans with liver disease