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Events leading to discontinuation occurred in 13.2% of the semaglutide group and 11.9% of the placebo group, and 26% of participants overall permanently discontinued semaglutide or placebo

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There is no universal medical requirement to gradually taper or wean off GLP-1 receptor agonists when discontinuing treatment

Slower escalation may reduce gastrointestinal side effects and moderate rapid weight shifts

Monitor Symptoms: Pay extra attention to your stomach and energy levels during the week you make the change