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Reductions in total cholesterol were significantly greater in participants treated with oral semaglutide 7 mg and 14 mg than in those treated with sitagliptin 100 mg (trial product estimand), which is also consistent with the PIONEER 3 trial results [18]
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Sakuma S, Ishimura M, Yuba Y, et al
In addition to the different study populations and study design in these trials, one potential reason for this heterogeneity in cardiovascular benefit is the structural differences among the GLP-1RAs used in these trials
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People with obesity often perceive tastes less intensely, and they have an inherently elevated desire for sweet and energy-dense food, explained Mojca Jensterle Sever, of the University Medical Centre in Ljubljana, Slovenia
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