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Interestingly, the generation of R-2-HG from glutamine has been proven to occur rapidly in patient-derived chondrosarcoma cell lines harboring endogenous IDH mutations, indicating fundamental metabolic differences between cells that harbor IDH1/2 mutations and those that do not 121

There is no fixed time frame to reach the maximum dosage

In clinical trials of adults without diabetes (SURMOUNT-1), patients treated with tirzepatide for chronic weight management lost an average of 1521% of their body weight over 72 weeks, depending on the dose used

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Native GLP-1 and AMG 133 both induce complete agonism of human GLP-1R, with respective EC 50 values of 4.1 and 24.4 pM (Extended Data Fig