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Some, but not all, observational studies have found that elderly individuals with lower status of folate and/or vitamin B 12 may have poorer memory performance, especially episodic memory (i.e., memory of events, times, and places) (108-111)

Its overexpression in aged mice alleviated mitochondrial protein-folding stress, resulting in enhanced neurogenesis and improved cognitive outcomes

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doi:10.1111/j.1749-6632.1989.tb14973.x

The multi-targeted actions of MANF underscore its potential as a candidate molecule in the treatment of neurodegenerative diseases [151]