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These medications should also be used cautiously in individuals with certain medical conditions, such as epilepsy, untreated hypothyroidism, obesity, hyperglycemia, or elevated levels of plasma fatty acids, as these conditions may increase the risk of adverse effects or alter the drugs response

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The subjects response time or motor function may become slightly impaired or decreased after administration of higher doses

Elevated circulating IGF-1 led to an activation of the IGF-1PI3KAkt signalling pathway, causing augmented mTOR phosphorylation and higher phospho-FoxO/total FoxO ratio in skeletal muscle of LC supplemented rats [33]