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Visible fat loss results generally appear after three to four weeks when combined with regular exercise and a balanced diet
Note: The lower initial dose (2.5 mg weekly) is intended to reduce GI symptoms
Besides vaginal birth and being heavily overweight, one of the causes for POP is diminished vaginal tissue stiffness through the reduction of collagen with age and hormonal changes 128,129
Knowing when to escalate concern is an important aspect of safe self-management
However, a significant amount of skeletal muscle mass was also lost (1.4 kg or 3 lb), but this was found to be significantly less than the loss of fat mass at 5.6 kg (12.3 lb)
Additionally, nanocarriers designed for site-specific release can reduce the required dosage and mitigate potential cytotoxic effects
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