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In contrast, the bulkier Y37 rAmy in rAmy-bound AMY 2 R prevents equivalent interactions of N35 rAmy with RAMP2, and instead the bulkier Y37 rAmy forms interactions with E101 RAMP2 and F111 RAMP2 stabilising the peptide at the CTR/RAMP ECD interface in the bypass conformation
Around two-thirds of drugs that met the 1938 safety requirement failed the 1962 efficacy bar
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10.1016/j.cmet.2016.05.004 44 MllerT
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