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They require medical supervision, with NICE providing specific guidance on their use in type 2 diabetes (NG28) and obesity

It can be taken at a consistent time each day and used alongside other supplements depending on personal preference

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All the remaining authors declare no competing interests

Our functional and structural data, along with molecular dynamics (MD) simulations, suggest that receptor conformational dynamics associated with flexibility of the peptide N-terminal activation domain may be a key determinant of agonist efficacy