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doi :10.1089/acm.2010.0716 Winkler BS, Orselli SM, Rex TS

The study suggests Polyscias fulva may exert its effects by regulating the HIF1A , ESR1 , EGFR , and CASP3 genes, promoting caspase-3 expression, and suppressing HIF-1, ER, and EGFR expression [Citation135]

However, these do have to be prescribed and administered by a healthcare professional, and are more likely to be given to people who have lifelong conditions affecting their ability to absorb B12 or who are at higher risk of consistent deficiency