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In contrast to these results, a study using nationwide registry data from Sweden, Denmark, and Norwayinvolving 121,254 new GLP-1 RA users and 185,027 new SGLT-2 inhibitor users documented 557 intestinal obstruction events, with no significant correlation between GLP-1 RA use and increased intestinal obstruction risk, thereby refuting earlier safety concerns [12]

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Either Trx1 or Grx1 are required for each turnover of RNR, the essential enzyme for deoxyribonucleotides synthesis during DNA replication and repair