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doi: 10.1002/art.23591 36 ShahraraSProudfootAEWoodsJMRuthJHAminMAParkCCet al

Using HEK-293 adherent cells and K-562 suspension cells treated with varying concentrations of menadione or l-Buthionine Sulfoximine (BSO), two compounds known to affect total glutathione (GSH + GSSG) levels, we assayed the cells in separate assays and in a multiplex assay

Notably, H1, Igl2, E3, F6, T7, S8, L10, D12, and Y14 of SR18 demonstrate similar interaction patterns with K 197 , L 201 , R 299 , W 306 , L 384 , and L 388 of GLP-1R

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Both peptides trigger this release through the growth hormone secretagogue receptor (GHS-R) not the normal growth hormone-releasing hormone (GHRH) pathway

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