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However, due to high heterogeneity among studies and generally short intervention durations, these findings should be interpreted cautiously

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*JAMA Internal Medicine*, 173(5), 386-388

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Emerging evidence suggests that natural products derived from medicinal plants, dietary components, animals, and microorganisms may modulate PCD in granulosa cells through various molecular mechanisms and signaling pathways

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20-bp guide RNA sequences were designed using the CRISPR Design Tool ( and expressed along with Cas9 using the plentiCRISPRv2 vector, which was a gift from Feng Zhang (Addgene plasmid # 52961

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